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Multiple system atrophy (MSA) is a neurodegenerative condition which is entirely unrelated to the similar sounding multiple sclerosis (MS). However, the Syn-One test will be negative if the symptoms are caused by diabetic autonomic neuropathy, medications, or irritable bowel syndrome, among other causes. All three of these conditions will show a positive Syn-One test. Autonomic dysfunction can be seen in PD, multiple system atrophy, and pure autonomic failure (PAF). Patients with dizziness upon standing due to blood pressure drops (orthostatic hypotension), constipation, abnormal sweatiness, and urinary dysfunction may be experiencing reduced function of the autonomic nervous system, meaning the nerves which control the visceral organs. However, it cannot differentiate between PD and DLB, as both will show positive results on the Syn-One test.
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The Syn-One test can differentiate between DLB and other causes of dementia such as Alzheimer’s disease and vascular dementia. Syn-One can differentiate between conditionsĭementia with Lewy bodies is a form of cognitive decline (dementia) associated with Parkinson’s-like tremor, slowness, and/or gait issues, often with hallucinations or other behavioral changes. It can also help in cases of slowing and stiffness to differentiate between normal aging or arthritis vs PD. The Syn-One test can thus be useful in differentiating between tremor due to Parkinson’s disease vs other causes of tremor (most commonly essential tremor or medication-related).